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Figure 4: Development of wild-type and Δp52 parasites in primary human hepatocytes.(A) Parasites at 20 hours. Extracellular parasites are visualised by staining with anti-PfCSP antibodies (secondary conjugated with ALEXA594, i.e. red fluorescence) before permeablisation (α-PfCS*) and all parasites are visualised by staining with anti-PfCSP antibodies (secondary conjugated with ALEXA488 i.e. green fluorescence) after permeablisation (α-PfCS**). The nuclei of the host cells are stained with DAPI (blue). (B) Parasites at day 3 or day 5. Nuclei of both the host cell and the merozoites inside the developing schizont are visible by DAPI staining (blue). Parasites are identified by anti-HSP70 staining (α-HSP70; secondary antibody conjugated with ALEXA488; green). Parasite lacking P52 expression fail to develop into schizonts and the only visible forms of the parasite are small ‘rounded’, possibly degenerate and/or extracelluar, forms. Scale bars in the DAPI panels represent a size of 10 µM.
Image Text (High Precision): DAPI p52
Other Images from "Gene Disruption of Plasmodium falciparum p52 Results in Attenuation of Malaria Liver Stage Development in Cultured Primary Human Hepatocytes":
Figure 1 Generation of P. falciparum parasites la...
Figure 2 Gliding Motility and Traversal Capacity ...
Figure 3 Invasion capacity of Wt and Δp52 sporozo...
Figure 4 Development of wild-type and Δp52 parasi...